Tuesday, April 15, 2014

WEBDuBois: any "race is going to be saved by its exceptional men" & women


The Negro race, like all races, is going to be saved by its exceptional men. The problem of education, then, among Negroes must first of all deal with the Talented Tenth; it is the problem of developing the Best of this race that they may guide the Mass away from the contamination and death of the Worst, in their own and other races. Now the training of men is a difficult and intricate task. Its technique is a matter for educational experts, but its object is for the vision of seers. If we make money the object of man-training, we shall develop money-makers but not necessarily men; if we make technical skill the object of education, we may possess artisans but not, in nature, men. Men we shall have only as we make manhood the object of the work of the schools—intelligence, broad sympathy, knowledge of the world that was and is, and of the relation of men to it—this is the curriculum of that Higher Education which must underlie true life. On this foundation we may build bread winning, skill of hand and quickness of brain, with never a fear lest the child and man mistake the means of living for the object of life. . . .

  • If this be true—and who can deny it—three tasks lay before me; first to show from the past that the Talented Tenth as they have risen among American Negroes have been worthy of leadership; secondly, to show how these men may be educated and developed; and thirdly, to show their relation to the Negro problem. . . .
  • From the very first it has, been the educated and intelligent of the Negro people that have led and elevated the mass, and the sole obstacles that nullified and retarded their efforts were slavery and race prejudice; . . .
  • MAlexander: [shift criminal entrepreneurs from drug to thieving,pimping&c]


    The drug war is stupidity, wastefulness and futility on a colossal scale, and the results speak for themselves: prisons crammed with hundreds of thousands of nonviolent drug users, prohibitionist policies that ensure drug profits fuel criminal gangs rather than legitimate businesses, and police forces that employ ever more aggressive and draconian tactics in a futile attempt to stem the flow of a product for which there’s enormous demand.

    NDX v Populists: "civic startup" v "challenge to EU integration" &c

    does sv really want voter engagement ...


    Big tech-industry players want to help get out the vote and are pouring millions into a new startup to boost American civic engagement.
    The company, called Brigade, is designed to combat a lack of political engagement and interest in all levels of government across America — although the firm’s road map is unclear at this time.


    Over the last couple of years, populist political parties have been growing in strength across the European Union. Even Germany has seen the rise of an overtly anti-EU party. In September 2013, the Alternative für Deutschland (AfD) came within a whisker of gaining seats in the Bundestag. The AfD’s one of the main objectives is for Germany to leave the euro area.
    Populist parties have established themselves with solid electorates. They now command a significant political weigh and are capable of shifting mainstream political debate. This situation poses a growing political challenge to the process of European integration itself and mainstream political parties, which are portrayed by populists as self-serving and corrupt. Furthermore, anti-EU parties have prodded mainstream parties across the European Union to harden their stance on Europe.
    Populist parties are defined particularly by their opposition to immigration and the European post-war project of political and economic integration. However, they are also highly critical of international capitalism and globalisation, reject the established socioeconomic and political systems and glorify national identity. This is combined with anti-establishment and anti-Brussels rhetoric. The most successful populist parties have appealed to members of the lower middle class as well as skilled and unskilled manual workers. These parties usually have protectionist tendencies as well.

    Bain: low returns through 2020

    if can't make high returns, can buy a house like Milken.


    Our analysis leads us to conclude that for the balance of the decade, markets will generally continue to grapplewith an environment of capital superabundance. Even with moderating financial growth in developed markets,the fundamental forces that infl ated the global balance sheet since the 1980s—fi nancial innovation, high-speedcomputing and reliance on leverage—are still in place. Moreover, as fi nancial markets in China, India and otheremerging economies continue to develop their own fi nancial sectors, total global capital will expand by half again,to an estimated $900 trillion by 2020 (measured in prevailing 2010 prices and exchange rates). More than anyother factor on the horizon, the self-generating momentum for capital to expand—and the sheer size the finan-cial sector has attained—will infl uence the shape and tempo of global economic growth going forward

    Med Startups: Splitrock latest VC to bail for cs & FIRE


    Split Rock Partners to concentrate on software and Internet services investments.

    FORTUNE -- Split Rock Partners is becoming the latest venture capital firm to move away from healthcare investing, Fortune has learned.
    The firm, which has offices in Minneapolis and Silicon Valley, always has been a "generalist" shop, with its healthcare practice focusing more on medical device startups than on pharma or biotech companies. But managing director Michael Gorman says that the medical device space has become more challenging in recent years, whereas software and Internet services opportunities have become more attractive.
    Going forward, that means that Split Rock will invest most of the remaining uncalled capital in its $300 million fund into tech startups, while being open to "select" healthcare opportunities. If and when Split Rock raises its next fund, however, all of its would be dedicated to tech.
    Not surprisingly, this change in strategy is having an impact on personnel. Healthcare-focused principal David Allison recently left to join Versant Ventures, and healthcare-focused managing directors Dave Stassen and Josh Baltzell will not be listed as partners on Split Rock's next fund. Stassen plans to retire, while Baltzell eventually will search for a new job. Both, however, plan to continue managing out the existing healthcare portfolio.

    UG: stroke recovery: minocycline & candesartan sequencing



    Minocycline—a tetracycline antibiotic with anti-inflammatory and MMP inhibitory effects—has been promising in stroke preclinical as well as phase I and II clinical trials. Candesartan- angiotensin II receptor blocker- improved outcome and enhanced neovascularization post stroke. Despite its failure to provide benefit in the SCAST trial, candesartan’s long history of success in preclinical studies leads us to further investigate the combination of candesartan with other promising agents in the management of ischemic stroke.
    Objective: We propose the combination of candesartan and minocycline as a potential treatment for ischemic stroke and we optimize the timing of administration for maximal benefit. We hypothesize that early minocycline administration- to reduce inflammation- followed by 7-day candesartan dosing- to stimulate angiogenesis- yields a better outcome than either alone. Due to opposing actions of both agents on MMPs, sequential rather than simultaneous administration maintains candesartan neovascularization potential.
    Methods: Wistar rats subjected to 90-minute middle cerebral artery occlusion (MCAO) were divided into 4 groups: Saline, Candesartan, Minocycline and combination. Neurobehavioral tests were performed 1, 3, 7 and 14 days after stroke. Brains were collected on day 14 for assessment of angiogenesis and infarct size. Human brain endothelial cell proliferation and tube formation were measured in vitro by BrdU incorporation and Matrigel tube formation assays.
    Results: Sequential therapy improved neurobehavioral outcome and infarct volume compared to saline or either treatment alone. When added after minocycline, candesartan was effective at stimulating angiogenesis. However, simultaneous treatment decreased endothelial cell proliferation and tube formation in vitro.
    Conclusion: Sequential rather than simultaneous treatment with candesartan and minocycline offers more benefit than either alone.

    Monday, April 14, 2014

    Mutton: 100% yoy price hike


    Mutton was averaging 334 cents a kilogram last week, far ahead of the 160c/kg to 170c/kg range it had at this time last year.